Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
The antibody detects endogenous level of total Rel protein.
Peptide-KLH. Peptide sequence around aa.501~505 (T-S-S-D-S) derived from Human Rel.
Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Store at -20°C for long term preservation (recommended). Store at 4°C for a short term use.
The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which also includes RELA (MIM 164014), RELB (604758), NFKB1 (MIM 164011), and NFKB2 (MIM 164012). These proteins are related through a highly conserved N-terminal region termed the ‘Rel domain,’ which is responsible for DNA binding, dimerization, nuclear localization, and binding to the NFKB inhibitor (MIM 164008) (Belguise and Sonenshein, 2007 (PubMed18037997)).
Copley RR et al. (2007) Genome Res. 17(9):1327-35.
Liu YW,et al.(2007) Cell Mol Life Sci. 64(24):3282-94.
Banerjee D, (2005) Immunity. 23(4):445-58.