Product Name | Elk-1(Ab-383) Antibody |
Host Species | Rabbit |
Clonality | Polyclonal |
Purification | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
Applications | IHC |
Reactivity | Hu Ms Rt |
Specificity | The antibody detects endogenous level of total Elk-1 protein. |
Immunogen | Peptide-KLH. Peptide sequence around aa.381~385 (T-L-S-P-I) derived from Human Elk1. |
Target Name | Elk-1 |
Alternative Name | ELK1; ETS-domain protein Elk-1. |
SDS-PAGE MW | 47kd |
Accession No | P19419; NP_001107595.1 |
Concentration | 1.0mg/ml |
Formulation | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Storage | Store at -20°C for long term preservation (recommended). Store at 4°C for a short term use. |
Application:
Immunohistochemistry: 1:50~1:100
Background
Elk-1 is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. Alternatively spliced transcript variants encoding the same protein have been found for this gene
Xing J, et al. (1996) Science. 273(5277): 959-963.
Janknecht R, et al. (1993) EMBO J. 12(13): 5097-5104.
Marais R, et al. (1993) Cell 73: 381-393.
Kortenjann M, et al. (1994) Mol Cell Biol. 14: 4815-4824.
Cavigelli M, et al. (1995) EMBO J. 14: 5957-5964.
Whitmarsh A J, et al. (1995) Science. 269:403-407.
Sizes | 100ul, 50ul |
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