GSK3b(Ab-9) Antibody

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GSK3b Antibody
GSK3b(Ab-9) Antibody

GSK3b(Ab-9) Antibody

Catalog No : 21002


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SKU: 21002. Category: .
Product NameGSK3b(Ab-9) Antibody
Host SpeciesRabbit
Clonality Polyclonal
PurificationAntibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
ApplicationsWB IHC IF
ReactivityHu Ms Rt     
SpecificityThe antibody detects endogenous level of total GSK3b protein, this antibody may cross-react with the GSK-3a due to high sequence homology.
ImmunogenPeptide-KLH.Peptide sequence around aa.7~11 (T-T-S-F-A) derived from Human GSK3b.
Target Name GSK3b
Alternative NameFactor A, GSK-3 beta, Protein kinase GSK-3-beta, kinase GSK-3 beta
SDS-PAGE MW46kd
Accession NoP49841; NP_001139628.1
Concentration1.0mg/ml
FormulationSupplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore at -20°C for long term preservation (recommended). Avoid Store at 4°C for a short term use.


Application:

Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:200

 

Background

Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin.

Fan G, et al. (2003) J Biol Chem. 278(52): 52432-52436.
Barry FA, et al. (2003) FEBS Lett. 553(1-2): 173-178.
Welsh, et al. (1996) Trends Cell Biol. 6: 274-279.
Srivastava A K, et al. (1998) Mol Cell Biochem. 182: 135-141.
Cross D. A, et al. (1995) Nature. 378: 785-789.

Sizes

100ul, 50ul

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