|Product Name||GSK3b(Ab-9) Antibody|
|Purification||Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.|
|Applications||WB IHC IF|
|Reactivity||Hu Ms Rt|
|Specificity||The antibody detects endogenous level of total GSK3b protein, this antibody may cross-react with the GSK-3a due to high sequence homology.|
|Immunogen||Peptide-KLH.Peptide sequence around aa.7~11 (T-T-S-F-A) derived from Human GSK3b.|
|Alternative Name||Factor A, GSK-3 beta, Protein kinase GSK-3-beta, kinase GSK-3 beta|
|Accession No||P49841; NP_001139628.1|
|Formulation||Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|Storage||Store at -20°C for long term preservation (recommended). Avoid Store at 4°C for a short term use.|
Western blotting: 1:500~1:1000
Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin.
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