GSK3β(Phospho-Ser9) Antibody

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Histone H3(Acetyl-Lys23) Rabbit Polyclonal Antibody

GSK3β(Phospho-Ser9) Antibody

Catalog No : 11002


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SKU: 11002. Category: .

Product Name

GSK3β(Phospho-Ser9) Antibody

Host Species

Rabbit

Clonality

 Polyclonal

Purification

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Applications

WB IHC IF

Reactivity

Hu Ms Rt

Specificity

The antibody detects endogenous level of GSK3 beta only when phosphorylated at serine 9.

Immunogen

Peptide-KLH.Peptide sequence around phosphorylation site of serine 9 (T-T-S(p)-F-A) derived from Human GSK3β.

Target Name

GSK3β

Alternative Name

Factor A, GSK-3 beta, Protein kinase GSK-3-beta, kinase GSK-3 beta.

Modification

Phospho-Ser9

SDS-PAGE MW

46kd

Accession No

P49841; NP_001139628.1

Concentration

1.0mg/ml

Formulation

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage

Store at -20°C for long term preservation (recommended). Store at 4°C for a short term use.

Application:

Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:200

 

Background

Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin.

Fan G, et al. (2003) J Biol Chem. 278(52): 52432-52436.
Barry FA, et al. (2003) FEBS Lett. 553(1-2): 173-178.
Welsh, et al. (1996) Trends Cell Biol. 6: 274-279.
Srivastava A K, et al. (1998) Mol Cell Biochem. 182: 135-141.

Sizes

100ul, 50ul

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